tagoaika – ページ 5 – Uehiro Division for Applied Ethics, Hiroshima University

Ethical, Legal, and Social Challenges of Human Brain Organoid Research

January 21, 2025 Ethical, Legal, and Social Challenges of Human Brain Organoid Research Human brain organoids, small structures grown from stem cells that replicate key aspects of human brain tissue, are a promising avenue for scientific research. These organoids can offer insights into brain development, neurological diseases, and the effects of various treatments. However, as the field of human brain organoid research advances, it brings with it a range of ethical, legal, and social issues that need careful consideration. A recent review by an international team of researchers highlights these concerns, calling for a responsible, multidisciplinary approach to guide future research in this field. Human brain organoids are typically created from human pluripotent stem cells, which have the ability to differentiate into various cell types, including neurons. By controlling the environment in which these cells grow, researchers can create tissues that mimic certain structures and functi

Event

【Workshop】 Exploring UNESCO’s Governance Potential in Neurotechnology: Balancing Human Rights and Legal Authority

December 16, 2024 【Workshop】 Exploring UNESCO’s Governance Potential in Neurotechnology: Balancing Human Rights and Legal Authority Back to News Top

Event

【Workshop】 International ELSI Workshop　’Ethics of Neurotechnology’

Jaunary 14, 2024 【Workshop】International ELSI Workshop　’Ethics of Neurotechnology’ 【Overview】　In recent years, there has been significant progress in the development of technologies for recording of and intervening in brain and nervous activity, called “neurotechnology.” While neurotechnology has a wide range of potential usage, from basic neuroscientific research to medical applications and even to entertainment, it also raises a number of ethical concerns. In this workshop, such ethical issues will be examined through international collaboration of ethicists to guide future development of neurotechnology. For more information Back to News Top

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Blastocyst

Blastocyst A structure that forms at an embryonic stage approximately 6–7 days after fertilization that is capable of developing into an individual under suitable conditions. 戻る

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Brain Organoid

Brain Organoid A three-dimensional brain tissue structure created by culturing pluripotent stem cells or similar cells. Pluripotent stem cells possess self-renewal capability and the ability to differentiate into all body cell types. ES cells (derived from the inner cell mass of a blastocyst 5–7 days post-fertilization) require a donated fertilized egg, whereas iPS cells (produced by introducing multiple genes into somatic cells like blood or skin) require donated blood or skin cells. 戻る

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Broad Consent

Broad Consent Obtaining consent from a cell donor to use their donated cells for a wide range of medical and scientific research purposes. 戻る

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DNA Methylation

DNA Methylation One of the main factors constituting the epigenome. When certain sites on DNA (containing genes) become methylated, the activity of these genes can change. 戻る

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Epigenome Editing

Epigenome Editing A technique to regulate or modify gene function without altering the DNA sequence itself. This involves adjusting mechanisms such as gene on/off switches and DNA methylation in targeted regions.

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ES Cells

ES Cells Pluripotent stem cells produced by extracting the inner cell mass from a blastocyst (which can potentially develop into a fetus and eventually into a human) and culturing it in vitro. One key feature of pluripotent stem cells is their ability to differentiate into virtually all cell types that constitute the human body, a property known as pluripotency. 戻る

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Germline

Germline A collective term for sperm, eggs, and all precursor germ cells. Genetic interventions carried out in these cells can affect future generations. 戻る

投稿者名:tagoaika